https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43306 Thu 15 Sep 2022 13:54:25 AEST ]]> A pharmacogenetic study implicates NINJ2 in the response to Interferon-ß in multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38338 -4, hazard ratio = 1.41). Moreover, rs7298096AA is associated with a higher NINJ2 expression in blood (p = 7.0 x 10-6), which was confirmed in vitro (p = 0.009). Finally, NINJ2 expression is downregulated by IFNβ treatment and related to TTFR. Conclusions: Rs7298096 could influence MS disease activity during IFNβ treatment by modulating NINJ2 expression in blood. The gene encodes for an adhesion molecule involved in inflammation and endothelial cells activation, supporting its role in MS.]]> Mon 30 Aug 2021 13:46:38 AEST ]]>